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Charlie Bradford, an aspiring filmmaker in his 30s, is doing the best he can to distance himself from the chaos of his childhood home. But his eccentric mother Linda, a compulsive hoarder who suffers from depression punctuated by spells of manic consumption, has a tendency to keep the people and things she loves close at hand. Charlie's younger sisters still live at home with Linda: Lisa, the older of the two has a history of petty theft and works as a home healthcare aid, and Penny, who is trying to overcome her agonizing shyness is starting a a new career as a home stager in a beleaguered real estate market. When a water stain on the family's garage door is interpreted as an apparition of the Blessed Virgin, the house attracts the unwanted attention of the neighbors... and the county health department, which gives the Bradfords a week to clean up their act or lose their home.