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Event
Advances in Down Syndrome Research
Join us for this educational session sponsored by the Heart of Illinois Down Syndrome Association, Inc.
Our speaker, Dr. Robert Schoen of Research Down Syndrome will share information regarding the latest findings in the area of cognitive research in individuals with Down syndrome.
ADVANCES IN DOWN SYNDROME COGNITIVE RESEARCH
Mild to moderate cognitive impairment is a hallmark of Down syndrome, yet Down syndrome cognitive research has been historically underfunded
As recently as 2004, there were no known biological mechanisms that contributed to Ds cognitive impairment
Since this time, thanks largely to non-government sourced research funds, dramatic progress has been made
Down syndrome results from an extra copy of Chromosome 21. The genes on Chromosome 21 are known, thanks to the Human Genome Project. Three copies of each Chromosome 21, rather than two, means that genes produce extra materials that lead to impaired cognitive function by impacting neuron system development and disrupting the signals sent between nerve cells that promote short term memory and learning.
Scientists, using mouse models that mimic Down syndrome in humans, have identified at least five pathways that contribute to cognitive impairment.
By understanding these impaired pathways, scientists can design pharmacological therapies that could limit cognitive impairment, and lead to improved memory, learning and communication.
SUMMARY OF DOWN SYNDROME COGNITIVE RESEARCH FINDINGS
At least five different sources of cognitive impairment have been identified in mice. These sources would be the target of drug therapies to improve cognition.
-In two sources of impairment, it is known that nerve cells are degenerated in Ds. This nerve cell degeneration has connections with Alzheimer's Disease.
-Two other sources of impairment are caused by the fact that messaging being transmitted between nerve cells is impaired.
-A fifth source of a potential target for drug therapy is the impaired formation of nerve circuits during development
A sixth potential drug target was identified in November, 2009. This target would be directed at an alternate source of impaired nerve cell circuitry that leads to impaired learning.
It is hoped that continued support in these areas will lead to clinical trials of drug therapies in humans. It is also import to fund initiatives that support the development of tests that can accurately measure memory and learning.
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LocationDunlap Middle School (View)
5200 W Cedar Hills Drive
Dunlap, IL 61525
United States
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| Non-Smoking: Yes! |
| Wheelchair Accessible: Yes! |
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